N-(3-hydroxyphenyl)-Arachidonoyl amide

N-(3-hydroxyphenyl)-Arachidonoyl amide (3-HPA) is an analog of AM404 (N-(4-hydroxyphenyl)-arachidonoyl amide), which is a selective inhibitor of carrier-mediated transport of arachidonoyl ethanolamide (AEA). 3-HPA is metabolized by both cyclooxygenase-1 (COX-1) and COX-2 and was found to selectively and irreversibly inhibit COX-2 with an IC₅₀ value of 2 μM.

N-(3-hydroxyphenyl)-Arachidonoyl amide is a selective, irreversible inhibitor of COX-2.

ChEBI: N-(3-hydroxyphenyl)-Arachidonoyl amide is an anilide.

2 μm

[1]. fitzpatrick, f. cyclooxygenase enzymes: regulation and function. current pharmaceutical design. 2004; 10(6): 577-588.