8-Prenylnaringenin, a strong plant-derived estrogen receptor ligand, is a phytoestrogen th at inhibits multidrug resistance-associated transporters, P-glycoprotein and MRP1. 8-Prenylnaringenin also inhibits EGF signaling at the level of phosphatidylinositol-3-OH kinase ((PI(3)K))activity.
This prenylated phytoestrogenic flavonoid (FW = 340.38 g/mol), isolated from hops (Humulus lupulus), inhibits cytochrome P450 systems CYP1A2 and CYP19, or aromatase. 8-Prenylnaringenin also inhibits angiogenesis in vitro and in vivo.
