JNJ-17203212 (0.3 mg/kg; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression[2].
JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner[2].
| Animal Model: | Male Sprague-Dawley rats (260-300 g)[2] |
| Dosage: | 0.3 mg/kg |
| Administration: | Intravenous injection |
| Result: | Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS. |
![4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide Structure](/CAS/GIF/821768-06-3.gif)