N-[[L-TRANS-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL]-L-LEUCYL-3-(P-HYDROXYPHENYL)ETHYLAMIDE
N-[[L-TRANS-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL]-L-LEUCYL-3-(P-HYDROXYPHENYL)ETHYLAMIDE
英文名称:N-[[L-trans-3-(Ethoxycarbonyl)oxiran-2-yl]carbonyl]-L-leucyl-3-(p-hydroxyphenyl)ethylamide
CAS号:262381-84-0
分子式:C20H28N2O6
分子量:392.45
EINECS号:
Mol文件:262381-84-0.mol
![N-[[L-TRANS-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL]-L-LEUCYL-3-(P-HYDROXYPHENYL)ETHYLAMIDE 结构式](https://img.chemicalbook.com/CAS/20200515/GIF/262381-84-0.gif)
N-[[L-TRANS-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL]-L-LEUCYL-3-(P-HYDROXYPHENYL)ETHYLAMIDE 性质
| 储存条件 | 4°C, protect from light |
|---|---|
| 溶解度 | DMSO:125.0(最大浓度 mg/mL);318.51(最大浓度 mM) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
N-[[L-TRANS-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL]-L-LEUCYL-3-(P-HYDROXYPHENYL)ETHYLAMIDE 用途与合成方法
JPM-OEt 是一种广谱的半胱氨酸组织蛋白酶 (cysteine cathepsin) 抑制剂。JPM-OEt 在活性位点共价结合，并且不可逆地抑制半胱氨酸组织蛋白酶家族。具有抗肿瘤活性。
JPM-OEt (50 mg/kg; i.p.; daily for 30 days) reduces tumor cathepsin B activity significantly.
JPM-OEt (50 mg/kg; i.p.; twice daily for 4 weeks) leads to tumor regression in the RIP1-Tag2 (RT2) mouse model of pancreatic islet cell tumorigenesis.
JPM-OEt (50 mg/kg; i.p.; daily from 63 to 98 days) causes a significant delay in the increase of tumour burden during the first 2 weeks of treatment.
| Animal Model: | Female mice of a transgenic mouse |
| Dosage: | 50 mg/kg |
| Administration: | i.p.; daily from 63 to 98 days |
| Result: | Caused a significant delay in the increase of tumour burden during the first 2 weeks of treatment. However, on days 84, 91 and 98 no significant differences between both groups could be detected. |
N-[[L-TRANS-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL]-L-LEUCYL-3-(P-HYDROXYPHENYL)ETHYLAMIDE 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-102087 | 1 mg | 2181 | ||
| 2024-04-30 | HY-102087 | N-[[L-TRANS-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL]-L-LEUCYL-3-(P-HYDROXYPHENYL)ETHYLAMIDE | 262381-84-0 | 5 mg | 4800 |
N-[[L-TRANS-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL]-L-LEUCYL-3-(P-HYDROXYPHENYL)ETHYLAMIDE供应商 更多
张家港阿拉宁生化技术有限公司
联系电话：0512-58900862 400-0707518
产品介绍：
英文名称：XSC-2
CAS：262381-84-0
纯度：>98% HPLC
包装信息：5mg; 25mg; 100mg; 1g; 5g; 25g;100g
备注：Peptide
ChemeGen 中国
联系电话： 18818260767
产品介绍：
英文名称：JPM-OEt
CAS：262381-84-0
纯度：98%
包装信息：10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注：品牌：ChemeGen
上海传芊化工科技中心
联系电话： 15869524721
产品介绍：
英文名称：JPM-OEt
CAS：262381-84-0
纯度：98% HPLC
包装信息：5MG;10MG;50MG;100MG,1G,5G,10G
