6-Chloro-1,3-dimethyl-5-nitrouracil is an intermediate used in the synthesis of 9-?(1,?3-?Dioxolan-?2-?ylmethyl)?-?3,?9-?dihydro-?1,?3-?dimethyl-1H-?purine-?2,?6-?dione (D486860), which is an isomer impurity in the synthesis of Doxofylline (D557100), a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as Theophylline and the evidence supporting the effects of Doxofylline in the treatment of lung diseases.