Hypobromous acid tert-butyl ester is prepared in 43% yield on a 0.18 mol scale by addition of t-butyl alcohol to a solution
of Ag2SO4 and bromine in water. The product is isolated by distillation. Since much material is lost during
the distillation, many workers have found it more convenient to prepare and use the reagent in solution. In
one procedure the reagent is generated in CH2Cl2 solution from Hg2O, bromine, and t-butyl alcohol. It has
also been prepared from NaBr, NaOCl, t-butyl alcohol, and acetic acid.
