AMinoiMinoMethanesulfonic Acid is a parent compound and its derivatives guanylate amines; some derivatives give triazoles with azide and aminoiminoethanenitriles with cyanide as nucleophile.
AMinoiMinoMethanesulfonic Acid can be used to prepare Guanidine derivatives.
Preparative Methods of AMinoiMinoMethanesulfonic Acid: by the oxidation of thiourea or aminoiminomethanesulfinic acid (formamidinesulfinic acid) with Peracetic Acid. Many substituted aminoiminomethanesulfonic acids can be prepared in the same way. Others have utilized Hydrogen Peroxide with sodium molybdate as a catalyst to oxidize the corresponding thioureas to a variety of monosubstituted aminoiminomethanesulfonic acids; the substituents include phenyl, 2-methylphenyl, 4-fluorophenyl, n-propyl, cyclohexylmethyl, S-α- methylbenzyl, cyclooctyl, and benzhydryl.
AMinoiMinoMethanesulfonic Acid is stable for at least a few weeks at room temperature. After drying, it remains stable for at least 5 months if kept in a freezer. Thiourea and its metabolites (probably oxidized thiourea) are tumorigenic and cause lung edema. All direct contact with the compound should be avoided; for example, a dust mask should be worn. All residues should be destroyed with strong bleach solution. Many substituted thioureas and their metabolites are also biologically active. Use in a fume hood.
