Benzamide, 4-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-

Light yellow crystal. Soluble in ether, insoluble in saturated saline. Encainide Hydroehloride: C22H28N2O2HCI.[66794-74-9]. White crystal, melting point 131.5-132.5℃. Soluble in water, slightly soluble in alcohol, insoluble in ether or pentane. Acute toxicity LD50 mice, dogs (mg/kg): 86, 43 oral; 16, 17 intravenous.

Encainide (MJ9067) is an antiarrhythmic agent with class IC activity. Encainide blocks voltage-dependent potassium channels. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research[1][2].

ChEBI: 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life- hreatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market.

[1] R N Brogden, et al. Encainide. A review of its pharmacological properties and therapeutic efficacy. Drugs. 1987 Nov;34(5):519-38. DOI:10.2165/00003495-198734050-00002
[2] Hongliang Li, et al. Encainide, a class Ic anti-arrhythmic agent, blocks voltage-dependent potassium channels in coronary artery smooth muscle cells. Korean J Physiol Pharmacol. 2023 Jul 1;27(4):399-406. DOI:10.4196/kjpp.2023.27.4.399