Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG[1].
| Animal Model: | Wistar rats (3 weeks old and 18 days pregnant)[1] |
| Dosage: | 0.3 μg |
| Administration: | Intracerebroventricular injection; 0.3 μg; once daily; 1-week |
| Result: | Inhibited GLT-1 protein levels and inhibited long-term depression in rats.
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