Histone H2AX, a variant of the nucleosome core histone H2A, undergoes phosphorylation on serine 139 in response to DNA damage, particularly when the damage involves formation of double-strand breaks. Phosphorylated H2AX is also termed γH2AX. Induction of γH2AX in cells exposed to genotoxic agents is considered a sensitive and specific reporter of DNA damage.1 This antibody reacts to γH2AX when phosphorylated at Ser139 and does not detect other phosphorylated histones.WARNING This product is not for human or veterinary use.
