17(S)-HDHA-d5 ethyl ester

17(S)-HDHA-d5 ethyl ester is intended for use as an internal standard for the quantification of 17-HDHA ethyl ester by GC- or LC-MS. 17(S)-HDHA ethyl ester is an esterified form of the hydroxy fatty acid and docosahexaenoic acid (DHA; Item Nos. 90310 | 17950) 15-lipoxygenase (15-LO) metabolite 17(S)-HDHA (Item No. 10009799). (±)17-HDHA is an autoxidation product of DHA, and 17(R)-HDHA is formed by aspirin-acetylated COX-2-mediated oxidation of DHA.1,2,3WARNING This product is not for human or veterinary use.

[1] M VANROLLINS  R C M. Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate.[J]. Journal of Lipid Research, 1984, 25 5: 507-517.
[2] REYNAUD D.  Paceasciak C R  Thickitt C P. Facile Preparation and Structural Determination of Monohydroxy Derivatives of Docosahexaenoic Acid (HDoHE) by α-Tocopherol-Directed Autoxidation[J]. Analytical biochemistry, 1993, 214 1: Pages 165-170. DOI: 10.1006/abio.1993.1472
[3] JULIA HOMANN . Chiral chromatography–tandem mass spectrometry applied to the determination of pro-resolving lipid mediators[J]. Journal of Chromatography A, 2014, 1360: Pages 150-163. DOI: 10.1016/j.chroma.2014.07.068