Bradykinin Fragment (1-5) (trifluoroacetate salt)

Bradykinin fragment (1-5) is a metabolite of the endogenous vasodilator bradykinin (Item No. 37408).1 It is formed from bradykinin by angiotensin-converting enzyme (ACE). Bradykinin fragment (1-5) (100 nM) increases the production of nitric oxide (NO) in neonatal rat cardiomyocytes.2 It inhibits α-thrombin-induced platelet aggregation of washed isolated platelets (IC50 = 0.5 mM).3 Bradykinin fragment (1-5) prevents decreases in mean arterial blood pressure and heart rate and increases survival in a rat model of LPS-induced septicemia.4WARNING This product is not for human or veterinary use.

[1] BEATA BUJAK-GIŻYCKA. Metabolism of bradykinin in aorta of hypertensive rats.[J]. Acta biochimica Polonica, 2011, 58 2: 199-202.
[2] IGOR MACIEL SOUZA-SILVA. Peptide fragments of bradykinin show unexpected biological activity not mediated by B1 or B2 receptors[J]. British Journal of Pharmacology, 2022, 179 12: 3061-3077. DOI: 10.1111/bph.15790
[3] A A HASAN  A H S  S Amenta. Bradykinin and its metabolite, Arg-Pro-Pro-Gly-Phe, are selective inhibitors of alpha-thrombin-induced platelet activation.[J]. Circulation, 1996, 94 3: 517-528. DOI: 10.1161/01.cir.94.3.517
[4] T A MORINELLI. A metabolic fragment of bradykinin, Arg-Pro-Pro-Gly-Phe, protects against the deleterious effects of lipopolysaccharide in rats.[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 296 1: 71-76.