SH3 and multiple ankyrin repe at domains 2 (SHANK2) protein is a multimodular scaffold protein present in the postsynaptic density (PSD). The PDZ domain of SHANK2 interacts with the C terminus of Phospholipase-β3 and brings it closer to Homer 1b for the regulation of mGluR-mediated calcium signal in the PSD region of neuronal synapses. Mutations in this gene have been linked to autism spectrum disorder and mental retardation.
