Phosphonium, [2-oxo-2-(2-propyn-1-ylamino)ethyl]triphenyl-, bromide (1:1)

WYneN (compound 10) is a functionalized Wittig-alkyne probe. WYneN exhibits strong reactivity with sulfinic acid dipeptide models, similar to the parent Wittig reagent. WYneN can be used to reveal the function of oxidative modifications on a proteome-wide scale[1].

[1] Shi Y, et al. Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting. Nat Chem. 2021 Nov;13(11):1140-1150. DOI:10.1038/s41557-021-00767-2