A 31472 is a tetracyclic spiro amine that has affinity for dopamine D-2 receptors. These compounds are important for defining the pharmacophore for D-2 antagonist activity due to their limited conformational freedom.
Uses
A31472 is a dopamine D-2 receptors antagonist that is promising for research of antipsychotic agents[1].
References
[1] Froimowitz M, et al. Conformational properties of semirigid antipsychotic drugs: the pharmacophore for dopamine D-2 antagonist activity. J Med Chem. 1991 May;34(5):1707-14. DOI:10.1021/jm00109a026
