Lipid AX4

Lipid AX4 is an ionizable cationic lipid with the pKa of 6.89， and can be used the study for the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo[1].

[1] Miao H, et al. Optimization of formulation and atomization of lipid nanoparticles for the inhalation of mRNA. Int J Pharm. 2023;640:123050. DOI:10.1016/j.ijpharm.2023.123050
[2] KE‐JUNG HUANG. Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-CoV-2 Delta Variant[J]. bioRxiv : the preprint server for biology, 2022, 25 1. DOI: 10.1101/2022.05.12.491597