Methanone, [1-(5-fluoropentyl)-2-methyl-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-

UR-144 is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral cannabinoid (CB₂) receptor (K_i = 1.8 nM) over the central cannabinoid (CB₁) receptor (K_i = 150 nM).¹ M-144 differs from UR-144 by having a fluorine atom on the terminal carbon of the alkyl group as well as a methyl group attached to the C₂ carbon of the indole. The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.

1. Frost, J.M., Dart, M.J., Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB₂ cannabinoid receptor activity J. Med. Chem. 53(1),295-315(2010).