氨磷汀硫化物
氨磷汀硫化物 性质
| 沸点 | 218.6±15.0 °C(Predicted) |
|---|---|
| 密度 | 0.975±0.06 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light, stored under nitrogen |
| 溶解度 | DMSO：< 1 mg/mL（不溶或微溶） |
| 酸度系数(pKa) | 10.00±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色 |
| 水溶解性 | Water: 250 mg/mL (1862.34 mM) |
氨磷汀硫化物 用途与合成方法
p53
Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures.
Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation.
Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation.
Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability.
Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment.
Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage.
Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81.
Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells.
