Fusapyrone is a broad specrum antifungal metabolite with low zoo-toxicity.
Fusapyrone is a broad spectrum antifungal metabolite isolated from several Fusarium species, first reported in 1994. Fusapyrone exhibits low zoo-toxicity as evidenced by a lack of toxicity against Artemia salina, and is a useful candidate for control of postharvest crop diseases. The mechanism of action of fusapyrone is unknown. The structure of fusapyrone was revised in 2006.
fusapyrone, a broad-spectrum antifungal metabolite, is isolated from several fusarium species.structurally, fusapyrone consists of a 4-deoxy-β-xylo-hexopyranosyl c-glycosyl moiety bound to the c-6 of the 2-pyrone ring and a highly functionalized aliphatic chain. fusapyrone exhibited low zoo-toxicity, as evidenced by a lack of toxicity against artemia salina. fusapyrone exerted considerable antifungal activity against several plant mycotoxigenic, pathogenic, and human pathogenic filamentous fungi, including aspergillus flavus, aspergillus niger, aspergillus parasiticus, and aspergillus fumigatus [1]. additionally, it had been investigated as a useful candidate for the control of postharvest crop diseases, including blocking the growth of ochratoxin-producing strains of aspergillus section nigri in wine grapes. however, fusapyrone was found to be ineffective toward yeasts isolated from fruits and plants and not toxic to artemia salina (brine shrimp). the mechanism of action of fusapyrone is unknown and the structure of fusapyrone was revised in 2006.
[1]. favilla, m., pascale, m., ricelli, a., evidente, a., amalfitano, c., & altomare, c. inhibition of species of the aspergillus section nigri and ochratoxin a production in grapes by fusapyrone. applied and environmental microbiology.2008; 74(7): 2248-2253.
