Pregna-1,4-diene-3,20-dione-4,6,21,21-d4, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-

Dexamethasone-d₄ is intended for use as an internal standard for the quantification of dexamethasone by GC- or LC-MS. Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (K_d = 5 nM versus 17 nM, respectively). Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.