Tyrosine kinase 2 (TYK2) is a member of the JAK family of non-receptor tyrosine kinases that has a key role in cytokine signaling.1,2 It is composed of an N-terminal FERM homology domain, which mediates protein-protein interactions, a Src-homology 2 (SH2) domain, a catalytically inactive pseudokinase domain, and a catalytically active C-terminal kinase domain.1 TYK2 is expressed by a variety of immune cells, including T and B cells, dendritic cells, mast cells, and macrophages, where it associates with numerous cytokine receptor chains, including IFNARI, IL-12Rβ1, IL-10R2, gp130, and IL-13Rα1, to mediate STAT-dependent cytokine signaling.2,1,3 TYK2 is activated by its phosphorylation, which is induced by ligand-bound cytokine receptors via JAK1 or JAK2-mediated transactivation, and is inhibited by suppressor of cytokine signaling (SOCS) proteins.3 TYK2 has roles in numerous immunological processes, including inflammatory and autoimmune diseases, pathogen defense, and allergy, as well as tumor surveillance and cancer.1,3 TYK2 SNPs have been identified in patients with acute myeloid leukemia, and TYK2 polymorphisms have been associated with systemic lupus erythematosus (SLE) and multiple sclerosis in humans.1 Cayman's TYK2 (human, recombinant) protein can be used for enzyme activity assays.WARNING This product is not for human or veterinary use.
