Ac-VEID-AMC (ammonium acetate salt)

Ac-VEID-AMC is a fluorogenic substrate based on the caspase-6 cleavage site in lamin A at amino acids VEID during apoptosis.1 It has also been reported to be cleaved by related proteases, including caspase-8.2 Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.WARNING This product is not for human or veterinary use.

[1] R V TALANIAN. Substrate specificities of caspase family proteases.[J]. The Journal of Biological Chemistry, 1997, 272 15: 9677-9682. DOI: 10.1074/jbc.272.15.9677
[2] HAN-JUNG CHAE. Je-chun-jun induced apoptosis of human cervical carcinoma HeLa cells.[J]. Acta Pharmacologica Sinica, 2004, 25 10: 1372-1379.