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1,2-Dimethyl hydrazine

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1,2-Dimethyl hydrazine Basic information
1,2-Dimethyl hydrazine Chemical Properties
  • Melting point:-8.9°C
  • Boiling point:87.05°C
  • Density 0.8274
  • refractive index 1.4209
  • pka9.29±0.70(Predicted)
  • Stability:Stable. Incompatible with oxidizing agents, water, moisture.
  • IARC2A (Vol. 4, Sup 7, 71) 1999
  • EPA Substance Registry System1,2-Dimethylhydrazine (540-73-8)
Safety Information
1,2-Dimethyl hydrazine Usage And Synthesis
  • Chemical Propertiescolourless or yellow hygroscopic liquid which fumes in air
  • Chemical Properties1,2-Dimethylhydrazine is a colorless or yellow hygroscopic liquid and releases fumes in air. 1,2-Dimethylhydrazine is stable and incompatible with oxidizing agents, water, and moisture. Hydrazines include 1,1-dimethylhydrazine and 1,2-dimethylhydrazine, collectively. Hydrazines in pure form are clear, colorless liquids that quickly evaporate in air. Hydrazines smell somewhat like ammonia. Hydrazines are highly reactive and easily catch fi re. 1,1-Dimethylhydrazine, and 1,2-dimethylhydrazine are somewhat similar in chemical structure and reactivity. However, there are some clear differences in their production, uses, and adverse health effects. There are many other hydrazine compounds. Hydrazines are manufactured from chemicals such as ammonia, dimethylamine, hydrogen perox- ide, and sodium hypochlorite. A small amount of hydrazine occurs naturally in some plants. Large amounts of hydrazines are in different countries. 1,2-Dimethylhydrazine is a research chemical and the quantities produced are likely to be much less. Hydrazine has been used as a fuel source for rocket propellant and spacecraft, including the space shuttle. Hydrazine is also used to treat boiler water to reduce corrosion and to reduce other chemical substances. Hydrazine is used as a medicine and in the manufacture of other medicines, farm chemicals, and plastic foams. 1,1-Dimethylhydrazine has been used as a rocket propellant and in the manufacture of other chemical substances, while the literature indicate that 1,2-dimethylhydrazine has no commercial use but is used in researches to study colon cancer in experimental animals.
  • Uses1,2-Dimethylhydrazine (SDMH) unlike its analog 1,1- dimethylhydrazine (UDMH) is used only in small quantities as a research chemical. There are no known commercial uses, although it was evaluated as a high-energy rocket fuel. The material is a fuming, strongly alkaline, moderately volatile liquid.
  • DefinitionChEBI: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
  • General DescriptionA colorless liquid with an ammonia-like odor. Less dense than water. Flash point is 5°F. Contact irritate skin, eyes, and mucous membranes. Very toxic by ingestion, inhalation and skin absorption. Used to make photographic chemicals.
  • Air & Water ReactionsHighly flammable. Fumes upon exposure to air . Soluble in water with evolution of heat.
  • Reactivity Profile1,2-Dimethyl hydrazine dissolves, swells, and disintegrates many plastics [USCG, 1999].
  • Health HazardBreathing of vapor causes pulmonary irritation, delayed gastro-intestinal irritation, tremors, and convulsions. Contact with skin or mucous membranes causes chemical burns. Can be absorbed through skin to cause systemic intoxication and convulsions.
  • Health HazardInhalation exposure to hydrazines, cause adverse health effects and poisoning to animals and humans. The symptoms of toxicity and poisoning include, but are not limited to, injury to the lungs, liver, kidney, vomiting, uncontrolled shaking, lethargy (sluggishness), coma, and neuritis (an infl ammation of the nerves), convulsions, tremors, seizures, and the CNS. Effects on the nervous system have also been seen in animals exposed to hydrazine and 1,1-dimethylhydrazine, but not to 1,2-dimethylhydrazine.
  • Safety ProfileConfirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, intravenous, subcutaneous, and intramuscular routes. Moderately toxic by inhalation. Human mutation data reported. A very dangerous fire hazard when exposedto heat, flame, or oxidizers. A hgh-energy propellant for liquid-fueled rockets. When heated to decomposition it emits toxic fumes of NOx
  • CarcinogenicitySDMH is carcinogenic to mice, rats, and hamsters using a variety of exposure routes. Oral doses of 21 mg/kg for 11 weeks produced intestinal tumors in rats. A lower dose (3 mg/kg) in drinking water for 12 months produced liver hemangioendotheliomas.A number of these tumors were metastatic. Mice given doses of 60–90 mg/day in drinking water developed a variety of tumors including angiosarcomas and lung adenomas . Both oral administration and intraperitoneal injection increased lung adenomas in the A/J strain mouse. Hamsters also developed angiosarcomas, intestinal tumors, and liver tumors following average daily intakes of 160 mg in drinking water. An in-depth description of the uniqueness of the colonic tumors was presented.
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