化合物 RF9 HYDROCHLORIDE 用途与合成方法
RF9 hydrochloride 是一种有效且有选择性的神经肽 FF 受体 (Neuropeptide FF receptor) 拮抗剂 ，对于 hNPFF1R 和 hNPFF2R 的 Ki 值分别为 58 和 7 nM。
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hNPFF1R 58 nM (Ki) |
hNPFF2R 75 nM (Ki) |
RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells.
RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance.
RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9.
| Animal Model: | Rats |
| Dosage: | 0.1 mg/kg. |
| Administration: | S.C. 30 min before 0.3 mg/kg heroin or saline on basal nociceptive threshold in rats. |
| Result: | Opposed to delaye heroin-induced hyperalgesia and associated tolerance. |
化合物 RF9 HYDROCHLORIDE供应商 更多
天津普西唐生物医药科技有限公司
联系电话：010-60605840 15801484223;
产品介绍：
英文名称：RF9 hydrochloride
纯度：98%
包装信息：5mg;10mg;50mg
