4-氯-2-甲基苯基硫氰酸酯
4-氯-2-甲基苯基硫氰酸酯 性质
| 熔点 | 115 °C |
|---|---|
| 沸点 | 471.2±35.0 °C(Predicted) |
| 密度 | 1.476±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 溶于DMSO(30mg/ml) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 稳定性 | 自购买之日起 2 年内保持稳定。 DMSO 溶液可在 -20°C 下保存长达 2 个月。 |
4-氯-2-甲基苯基硫氰酸酯 用途与合成方法
| Target | Value |
|
Kif18A
(Cell-free assay) | 1.69 μM |
BTB-1 blocks the motility of Kif18A in a reversible manner. BTB-1 inhibits Kif18A in an adenosine triphosphate (ATP)-competitive but microtubule-uncompetitive manner and slows down the progression of cells through mitosis. 100 μM BTB-1 does not significantly inhibit any of the other tested mitotic kinesins. BTB-1 competes with ATP for Kif18A binding only when the motor-protein is associated with its pseudosubstrate microtubules. HeLa cells treated with BTB-1 accumulate in mitosis in a dose-dependent manner. BTB-1 shows cell toxicity with an EC 50 values of 35.8 μM. HeLa cells treated with 50 μM BTB-1 reveals severe defects in spindle morphology and chromosome alignment. Treatment with high concentrations of BTB-1 does not result in elongated spindles.
4-氯-2-甲基苯基硫氰酸酯 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-101770 | 1 mg | 264 | ||
| 2024-11-08 | HY-101770 | 4-氯-2-甲基苯基硫氰酸酯 | 86030-08-2 | 5mg | 550 |
