2,2-DIFLUOROETHYLAMINE HYDROCHLORIDE

As a fluorinated aliphatic amine, 2,2-Difluoroethylamine hydrochloride can be used in preparation of wide range of pharmaceutical compounds including anti-tumor agents.

2,2-Difluoroethylamine hydrochloride was recently reported to be used as a precursor for the "elusive" difluoromethyl diazomethane species (CF₂HCHN₂). The difluoromethyl diazomethane intermediate can be generated in situ in the presence of tert-butyl nitrite and a catalytic amount of acetic acid.