Human milk samples were analyzed for the presence of IgA antibodies specific to certain antigens of H. pylori by western blot using alkaline-phosphate-conjugated goat anti-human IgA antibody.
Immunoglobulin A (IgA) is the most abundant antibody isotype produced in?humans. IgAs are heterogeneous and exist as two?IgA subtypes. It has the ability to form multimers by interacting with the joining (J) chain.It is present in large quantities in blood. IgA antibodies protect mucosal surfaces against invading pathogens.
Immunoglobulin A (IgA) antibody is?a?secretory?antibody present?abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. Thus, secretory IgA contributes to the humoral?defense?mechanism against the pathogens on mucosal?surfaces.
