GSK-3 β inhibitor 2
GSK-3 β inhibitor 2 性质
密度 | 1.475±0.06 g/cm3(Predicted) |
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酸度系数(pKa) | 13.08±0.20(Predicted) |
形态 | 固体 |
颜色 | 浅黄至黄色 |
GSK-3 β inhibitor 2 用途与合成方法
GSK-3β 1.1 nM (IC 50 ) |
The pyridine carboxamide of GSK-3β inhibitor 2 (Compound 3) makes hydrogen bonds with the hinge V135 backbone amide, and the carbonyl oxygen of the thiazolyl primary amide formed a critical hydrogen bond with K85. The quality of the electron density for the methyl group of the methoxy moiety in GSK-3β inhibitor 2 does not allow its unambiguous placement in the model, but a small molecule crystal structure of GSK-3β inhibitor 2 determined by single crystal X-ray diffraction method confirmed the intramolecular hydrogen bonding between the methoxy -O- and the amide N-H in GSK-3β inhibitor 2.
The elevation of hyperphosphorylated Tau (pTau) is mimicked in LaFerla 3xTg-C57BL6 mice, and accordingly, these mice are used as an in vivo model of Alzheimer’s disease. GSK-3β inhibitor 2 (Compound 3) shows a significant reduction in pTau396 when administered orally at 30 mg/kg as a nanosuspension to LaFerla 3xTg-C57BL6 male mice. GSK-3β inhibitor 2 shows only modest brain exposure (B/P = 0.26) as determined as a single time point.
GSK-3 β inhibitor 2 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024-08-19 | HY-130795 | GSK-3 β inhibitor 2 | 1702428-31-6 | 5mg | 1750 |
2024-08-19 | HY-130795 | GSK-3 β inhibitor 2 | 1702428-31-6 | 10mg | 2800 |