Dienamide A2 (24738-51-0) is an analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFα mRNA expression in human monocytes/macrophages via the CB2 receptor.1?Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively)2. It elevates intracellular Ca2+ levels in CB2-positive? but not in CB2-negative cells and this effect was blocked by SR144528.2??It significantly inhibits LPS-induced TNFα and IL-1β expression in a CB2-independent manner.2
Kalecide is a natural pesticide of Echinacea angustifolia, Echinacea atrorubens and Piper sarmentosum.
ChEBI: (2E,4E)-N-isobutyl-2,4-dodecadienamide is a fatty amide. It has a role as a metabolite.
1) Gertsch?et al. (2004), Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways; FEBS Lett., 577?563
2) Raduner?et al. (2006), Alkylamides from Echinacea are a new class of cannabinomimetics.? Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects; J. Biol. Chem., 281?14192
