LQZ-7I

Chemical Properties

Melting point	203 °C(Solv: ethanol (64-17-5))
Boiling point	470.3±45.0 °C(Predicted)
Density	1.390±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO: 125 mg/mL (358.83 mM)
form	A solid
pka	2.56±0.59(Predicted)
color	Light yellow to green yellow

Cell Line:	PC- 3 or C4-2 cells
Concentration:	10 μM
Incubation Time:	0-6 hours
Result:	Reduced the expression of survivin.

Animal Model:	6-week old male NSG mice
Dosage:	100 mg/kg; 200 μL vehicle (90% corn oil/10% DMSO)
Administration:	Oral gavage every other day for a total of ten treatments
Result:	Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.