RBM10 is an RNA binding protein and a paralog to tumor suppressor RBM5. Alternative splicing creates two highly expressed variants that differ by one exon. RBM10 controls alternative splicing and exon skipping of mRNAs, including Fas and Bcl-x. RBM10 has been shown to affect apoptosis via up regulation of TNF-α mRNA. In lung cancer, RBM10 mutations disrupt the splicing of NUMB, a regulator of Notch signaling. Fusion of the RBM10 gene with TFE3 has been found in renal cell carcinoma. Mutations of RBM10 causes TARP syndrome, an x-linked, lethal disorder characterized by various developmental defects.
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