Adenosine-3',5'-cyclic -monophosphorothioate

Product NameAdenosine-3',5'-cyclic -monophosphorothioate
CAS71774-13-5
MFC10H12N5O5PS
MW345.27
EINECS
MOL File71774-13-5.mol

Chemical Properties

Boiling point	648.0±65.0 °C(predicted)
Density	2.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
storage temp.	Desiccate at -20°C
solubility	water: 20 mg/mL
pka	-0.55±0.60(predicted)
form	crystalline solid
Water Solubility	water: 20mg/mL

Safety Information

WGK Germany	WGK 2
Storage Class	11 - Combustible Solids

Usage And Synthesis

Uses

(S)-Adenosine, cyclic 3'',5''-(hydrogenphosphorothioate) triethylammonium is an activator of PKA.

Definition

ChEBI: (Sp)-cAMPS is a nucleoside 3',5'-cyclic phosphorothioate having adenine as the nucleobase (the Sp-stereoisomer). It has a role as a protein kinase agonist. It is a member of purines and a nucleoside 3',5'-cyclic phosphorothioate. It is functionally related to a 3',5'-cyclic AMP.

Biological Activity

Cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor.

in vivo

In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 μg/μL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals^[5].

IC 50

PKA I; PKA II; PDE3A: 47.6 μM (Ki); PDE10 GAF domain: 50 μM (EC₅₀)