akt inhibitor iv is an inhibitor of akt activation that inhibits akt-mediated nuclear export of forkhead box class o transcription factor 1a (foxo1a; ic50 = 625 nm) and reduces phosphorylation of akt at ser473 and thr308 in a dose-dependent manner. akt inhibitor iv inhibits replication of parainfluenza virus 5 (piv5) in hela cells (ic50 = 520 nm). it also reduces the growth of cancer cells (ic50 = 0.3 μm for both jurkat and hela cells) via a reduction in mitochondrial polarization and increased production of reactive oxygen species (ros).
