Membrane bound O-acyl transferases (MBOATs) are a group of conserved, multiple transmembrane spanning enzymes involved in many biological functions including lipid biosynthesis, embryogenesis, nutrient sensing, and membrane lipid remodeling. This group of proteins is associated with pathologies such as diabetes, obesity, atherosclerosis, and Alzheimer’s disease. MBOAT1 functions as an acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity), and prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. The predicted size of MBOAT1 is 56.6 kDa, and Cayman''s MBOAT1 Polyclonal Antibody detects a band at approximately 60 kDa by western blot.
