Adrenomedullin (1-50) amide (rat) (trifluoroacetate salt)

Adrenomedullin (1-50) is a peptide hormone with RNA expressed in rat adrenal glands, lung, kidney, heart, and spleen, as well as in the duodenum and submandibular glands.1 The rat amino acid sequence is similar to human adrenomedullin (1-52) (Item No. 24889) but lacks two amino acids and contains six substitutions. Adrenomedullin (1-50) increases cAMP concentration in rat platelets (ED50 = 50 nM) and decreases mean blood pressure in anesthetized rats when administered at an intravenous dose of 1 nmol/kg. It reduces vascular hyperpermeability and increases survival in a rat model of α-toxin-induced septic shock.2 Adrenomedullin (1-50) also inhibits binding of human adrenomedullin to rat astrocytes in vitro (IC50 = 0.27 nM).3WARNING This product is not for human or veterinary use.

[1] SAKATA J. Molecular Cloning and Biological Activities of Rat Adrenomedullin, a Hypotensive Peptide[J]. Biochemical and biophysical research communications, 1993, 195 2: Pages 921-927. DOI: 10.1006/bbrc.1993.2132
[2] BETTINA TEMMESFELD-WOLLBRÜCK. Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock.[J]. Intensive Care Medicine, 2007, 33 4: 703-710. DOI: 10.1007/s00134-007-0561-y
[3] URS ZIMMERMANN . Identification of adrenomedullin receptors in cultured rat astrocytes and in neuroblastboma × glioma hybrid cells (NG108-15)[J]. Brain Research, 1996, 724 2: Pages 238-245. DOI: 10.1016/0006-8993(96)00337-x