Phentermine-d5 (CRM) is intended for use as an internal standard for the quantification of phentermine by GC- or LC-mass spectrometry. Phentermine is an α-methylated amphetamine that activates trace amine associated receptor 1 (TAAR1, EC50 = 5.47 μM). It potently stimulates the release of norepinephrine (IC50 = 39.4 nM), with less effect on the release of dopamine and serotonin (IC50s = 262 and 3,511 nM, respectively). Primarily through these actions, phentermine suppresses appetite and augments fat metabolism, supporting usefulness in ameliorating obesity.
