A tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity). Shown to be a weak inhibitor of trypsin-like proteasomal activity.
Cell permeable: no', 'Primary Target
branched chain amino acid preferring,small neutral amino acid preferring, chymotrypsin-like activities', 'Product does not compete with ATP.', 'Reversible: no', 'Target Ki: 1.5 μM, 2.3 μM, and 40.5 μM against branched chain amino acid preferring, small neutral amino acid preferring, and chymotrypsin-like activities of proteasomes, respectively
