Prostaglandin D
2 (PGD
2) is one of the five primary enzymatic prostaglandins derived directly from PGH
2. Many of the biological effects of PGD
2 are transduced
in vivo by a classical 7-
transmembrane GPCR, the DP
1 receptor.
1 However, a second receptor, the chemokine-
related CRTH2 receptor, also binds PGD
2.
2,3 This new receptor was recently identified on human eosinophils, where it binds selectively the PGD
2 metabolite 13,14-
dihydro-
15-
keto PGD
2.
4 11-
deoxy-
11-
methylene-
15-
keto PGD
2 was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-
deoxy-
11-
methylene-
15-
keto PGD
2.
1. Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor J. Biol. Chem. 270(32),18910-18916(1995).
2. Gervais, F.G., Cruz, R., Chateauneuf, A., et al. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP J. Allergy Clin. Immunol. 108(6),982-988(2002).
3. Monneret, G., Gravel, S., Diamond, M., et al. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor Blood 98(6),1942-1948(2001).
4. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 J. Exp. Med. 193(2),255-261(2001).
