Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB

Product NameFmoc-PEG3-Ala-Ala-Asn(Trt)-PAB
CAS2055042-69-6
MFC60H66N6O11
MW1047.22
EINECS
MOL File2055042-69-6.mol

Chemical Properties

Boiling point	1276.5±65.0 °C(Predicted)
Density	1.254±0.06 g/cm3(Predicted)
pka	11.60±0.46(Predicted)

Usage And Synthesis

Uses

Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

In vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Description

Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB PAB is a unique peptide cleavable ADC linker for antibody-drug-conjugation, PEG spacer increases the aqueous solubility.

Uses

Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268