Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH

A highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitory peptide that contains the Antennapedia transport peptide sequence fused to the N-terminus of autocamtide inhibitory peptide-II (AIP-II). AIP-II is an AIP analog where Ala³ and Val¹⁰ are replaced by Lys and Phe residues. AIP-II is reported to be more potent than CaMK-(281-302/Ala²⁸⁶) and KN-93. Inhibits by binding to the autophosphorylation site, which is distinct from the exogenous substrate-binding site.

Cell permeable: yes', 'Primary Target
cam Kinase-2', 'Product does not compete with ATP.', 'Reversible: no