(+)-Biotin-PEG6-NHS Ester

Biotin-PEG6-NHS ester is an amine reactive biotinylation reagent that can couple with amino (-NH2) containing molecule. The NHS group reacts specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds. he hydrophilic PEG spacer increases solubility in aqueous media.

Biotin-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005