AEA acts as an endogenous mimic of Δ9-THC, the psychotropic component of marijuana. oxy-AEA is the O-alkyl-N-acyl oxyhomologue of AEA. oxy-AEA is selective for the peripheral cannabinoid (CB2) receptor with Ki values of 0.47 and 0.081 μM for hCB1 and hCB2, respectively. In comparison, AEA has a greater affinity for the central cannabinoid (CB1) receptor with Ki values of 0.07 and 0.18 μM for hCB1 and hCB2, respectively. oxy-AEA is the first known fatty acid amide with a reversed CB1/CB2 affinity ratio.
oxy-Arachidonoyl ethanolamide (O-alkyl-N-acylhydroxylamine) is an O-alkyl-N-acyl oxime derivative[1].
ChEBI: Oxy-Arachidonoyl Ethanolamide is a primary alcohol.
[1] Sultan Mayar, et al. Examining Changes in Gramicidin Current Induced by Endocannabinoids. bioRXiv. 2024.11.05.622072.
