HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50s = 8, 12, and 4 μM, respectively). It less effectively blocks the activity of myosin light chain kinase (IC50 = 240 μM).
HA-100 dihydrochloride is an inhibitor of MYLK, PKA, and PKC.
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[2] krebs e g. protein kinases[j]. current topics in cellular regulation, 1972, 5: 99-133.
