AMG 837

AMG 837 (0.03-0.3 mg/kg; a single p.o.) improves glucose tolerance and enhances insulin secretion in Sprague-Dawley rats^[1].
AMG 837 (0.03-0.3 mg/kg; p.o. once daily for 21 days) reduces glucose levels and increases insulin levels following glucose challenge in vivo^[1].
AMG 837 (0.5 mg/kg; p.o.) displays excellent oral bioavailability (F=84%) and a total plasma C_max of 1.4 μM^[1].