Glucagon Receptor Antagonist, Control

Glucagon receptor antagonist inactive control is an analog of glucagon receptor antagonist I .¹ It inhibits glucagon binding to the glucagon receptor (GCGR) by only 20% in CHO cells expressing human GCGR when used at a concentration of 10 μM. Glucagon receptor antagonist inactive control has no effect on glucagon-induced glycogenolysis in primary human hepatocytes when used at concentrations of 10 or 30 μM.

1. Qureshi, S.A., Candelore, M.R., Xie, D., et al. A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects Diabetes 53(12),3267-3273(2004).