Azido-PEG10-alcohol

Product NameAzido-PEG10-alcohol
CAS877239-09-3
MFC20H41N3O10
MW483.56
EINECS
MOL File877239-09-3.mol

Chemical Properties

storage temp.	Storage temp. 2-8°C
solubility	Soluble in Water, DMSO, DCM, DMF
form	Liquid
color	Colorless to light yellow

Usage And Synthesis

Description

Azido-PEG10-alcohol is a aqueous soluble linker regent containing an click chemistry azide group and a terminal hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Azido-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG10-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005