5-Acetoxymethyl-2'-deoxyuridine can be used for a method is described for the solid-??phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-??(hydroxymetyl)??-??2'-??deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-??(hydroxymethyl) group.
