2-Nitro-3-pivaloyloxypropene

2-Nitro-3-pivaloyloxypropene is a multicoupling reagent; reacts stepwise with two different nucleophiles.

2-Nitro-3-pivaloyloxypropene (NPP) is prepared in four steps from Formaldehyde, Nitromethane, and pivaloyl chloride (ca. 25% overall yield at a 0.7 mol scale.[1]

2-Nitro-3-pivaloyloxypropene can be stored six months at -10 °C without decomposition. Use in a fume hood.

1. Seebach, D.; Knochel, P. HCA 1984, 67, 261.