Propargyl-PEG3-t-butyl ester

Product NamePropargyl-PEG3-t-butyl ester
CAS1374658-84-0
MFC14H24O5
MW272.34
EINECS
MOL File1374658-84-0.mol

Chemical Properties

Boiling point	337.2±27.0 °C(Predicted)
Density	1.023±0.06 g/cm3(Predicted)
storage temp.	2-8°C, stored under nitrogen
form	Liquid
color	Colorless to light yellow

Usage And Synthesis

Description

Propargyl-PEG3-t-butyl ester consists of an alkyne group and a t-butyl ester group. The alkyne groupreacts with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The protected carboxyl group can be deprotected under acidic conditions.

Uses

Propargyl-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005