Orfamide B is a cyclic lipopeptide originally isolated from P. fluorescens. It is the main orfamide produced by Pseudomonas sp. CMR12a. Orfamide B inhibits mycelial growth and increases hyphal branching in the fungi R. solani AG2-1 at concentrations of 10 and 100 μM and in R. solani AG 4-HGI at a concentration of 100 μM.
Orfamide B is a cyclic lipopeptide produced by Pseudomonas fluorescens.
Orfamide B is a component of a family of cyclic lipopeptides produced by Pseudomonas fluorescens, reported in 2007. The orfamides were discovered by employing genomic analysis with an isotope-guided fractionation to identify metabolites produced by orphan gene clusters containing non-ribosomal peptide synthetases. Orfamide B has not been further investigated, although its activity is thought to parallel that of orfamide A and other cyclic lipopeptides produced by Pseudomonas.
